The Breakthrough Prize in Science is an annual award given to scientists who have made significant contributions to the fields of life sciences, fundamental physics, and mathematics. The award was established in 2012 by Yuri Milner, a Russian entrepreneur and philanthropist, and his wife Julia Milner. The award is given out in three categories: Life Sciences, Fundamental Physics, and Mathematics. Each category has five winners, who receive a $3 million prize. The winners are selected by a committee of leading scientists in the respective fields. The award ceremony is held annually in Silicon Valley, California.